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Deltasone tablets 10mg, 30mg, or 50mg) placebo. In a parallel randomized controlled trial, 4,5,7 g/day of fenugreek sprouts, or placebo (n=60), was administered for 12 weeks to 50 healthy male and female volunteers. This is the first human study indicating any adverse effects of fenugreek supplementation. For more information about this study see: Bhatnagar et al. 2002 [15] Pharmaceutical and Natural Product Database, PubMed/Medline Plus/Pubmed, August 2nd, 2015 Hepatotoxicity In a study involving rats, consumption of 300, 900, and 1600 mg/kg of fenugreek/day by either a single dose (1.5-2.5 g) or a repeated dosing schedule at 4 week intervals (0.2, 0.4, & 0.7 g/kg/day for 4 weeks) did not cause hepatotoxicity [13]. In the same study, a dose of 200 to 300 mg/kg fenugreek/day produced no toxic effect upon liver function tests. In a study involving rats, consumption of 100-120 mg/kg Fenugreek extract daily for 3 months produced no significant change in BUN, ALT, GGT, AST, and bilirubin levels (BUN: 0.5; ALT: 5; GGT: AST: 4; bilirubin: 0.2), compared to control treatment. However, supplementation for 12 weeks resulted in a significant increase serum GGT and ALT. The authors speculated that GGT increase may be due to increased absorption (due the greater bioavailability of fenugreek) or alteration in the liver enzymes [16]. In a study involving rats, consumption of 200 to 300 mg/kg fenugreek/day produced no significant effect upon liver function tests, when compared to control treatment. However, supplementation for 12 weeks resulted in a significant increase serum GGT and ALT [11]. This study revealed that the GGT concentration in serum did not increase significantly after supplementation. This difference is likely caused by the relatively high dose employed as the rats were tested on a regular basis (21 mg/kg/d). A study involving rats used double-blind design, with each group receiving the same supplemental dose of fenugreek and extracts as a single dose or repeated dosing schedule of 4 weeks. The researchers found no significant changes in ALT, GGT, GSH, AST, drug store online shopping ALP, TG, and AST/ALP ratio in these animals after 3 to 12 weeks of supplementation. These rats were also free of disease and had a normal diet. No serious adverse events resulting from administration of 800 mg/kg fenugreek were observed. In a clinical trial How much finasteride for hair loss using oral fenugreek deltasone 5 mg (100 mg/kg/day of extract), liver disease occurred in only 0.07% of the rats treated (1 mg/kg/d) compared to 3% of the control rats and 0.01% of receiving fenugreek at 400 mg/kg/day and 1 g/kg/d. Hereditarian Use in Humans The herb is currently sold in the United States as Fenugreek Seed Co. (Londrina, FL).
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Deltasone 2.5 mg /kg/d intravenous injection). The patients were treated for 30 d with prednisone deltasone 20 mg tablet prednisone 2.5 mg/kg/d or saline, whichever was selected first, and the dose was increased according to the results of laboratory tests. On the basis of results obtained they were treated with an additional dose of prednisone 2.5 mg/kg/d or saline, whichever was chosen first. Table 1 summarizes the findings of study with subcutaneous administration prednisone. The incidence of adverse events was lower with subcutaneous administration compared intravenous administration. The primary adverse events were injection site reaction, such as pain or swelling, erythema, redness, and itchiness; muscle pain, fatigue, dizziness, or myalgia; and fatigue. Other reported adverse events of a minor nature were: nausea and vomiting, headache, diarrhea, insomnia. Table 1. Adverse Events in Patients With Endocarditis During Treatment Prednisone 2.5 or Prednisolone 500 mg Intravenously in Patients With Endocarditis Adverse Event Subcutaneous Pprednisone Subcutaneous Pprednisolone Prednisolone After Subcutaneous Prednisone After Subcutaneous Pprednisoltone Pprednisolone After Pprednisolone Time (h) (median) (interquartile range) I 2, % Pain 24 (21–28) 18 (15–24) 44 (36–48) 19 (17–28) 2 (1–6) 33 (27–41) 3,6 (2.3–6.9) Nervous system: headache 11 (9–14) 18 (15–26) 36 (30–42) 21 (16–30) 3 (2–6) 26 (22–30) 7,6 (5.5–13.5) Nervous system: dizziness 3 (2–6) 13 (11–17) 14 (10–21) 4 (3–6) 0 (0–4) 12 (9–16) 36 (30–46) Tremor 5 (4–7) 22 (19–26) 23 (20–26) 7 (5–12) 17 (9–30) 12 (8–20) 13,5 (10–25) Other: myalgia 8 (7–10) 11 (9–13) 31 (28–34) 9 (7–15) 8 (6–13) 42 (39–48) 17,6 (14–34) Other: confusion 2 (1–4) 1 (0–2) 30 (25–35) 4 (3–6) 29 (23–37) 6,6 (4–11) Other: sleepiness 7 (6–9) 2 (1–4) 12 (10–14) 5 (4–6) 22 (17–27) 5,8 (3–9) Gastrointestinal: indigestion 5 (4–7) 24 (21–26) 31.
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